ACTH 1-39 (Adrenocorticotropic Hormone, 39 amino acids)

Product Classification

- Classified as a melanocortin peptide hormone fragment

Description

ACTH 1-39 is an endogenous polypeptide hormone segment derived from proopiomelanocortin (POMC).
It stimulates adrenal cortex activity, leading to corticosteroid synthesis and secretion, primarily cortisol.
Research focuses on hypothalamic-pituitary-adrenal (HPA) axis regulation, stress signaling, and
inflammatory modulation.

Specifications

• Molecular Formula: C207H308N56O58
• Molecular Weight: ~4541 g/mol (approximate values vary by source)
• Sequence Length: 39 amino acids
• Mechanism: HPA axis activation via melanocortin receptor engagement

Research Notes

• Immunomodulation: research indicates potential interactions with inflammatory pathways and cytokine regulation.
• Analgesic & Neuromodulatory: melanocortin peptides are implicated in pain modulation, neuroendocrine signaling, and autonomic responses.
• Metabolic Regulation: cortisol-mediated pathways influence glucose metabolism, lipid mobilization, and hepatic output.
• Stress Axis Studies: utilized in research models examining HPA axis dysregulation and stress hormone feedback systems.
• Endocrine Effects: stimulates glucocorticoid production through adrenal cortex signaling.