AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide)

Product Classification

Classified as an AMP analog and AMPK activator

Description

AICAR is a nucleotide analog that enters cells and is phosphorylated to ZMP (AICAR monophosphate),mimicking AMP.
Activation of AMPK impacts cellular energy homeostasis, fatty acid oxidation, glucose uptake, and mitochondrial biogenesis.

Specifications

• Molecular Formula: C9H14N4O5
• Molecular Weight: 258.23 g/mol
• Mechanism: AMPK Activation via AMP Mimicry

Research Notes

• Metabolic Effects: increases AMPK signaling and promotes fatty acid oxidation and glucose uptake in skeletal muscle.
• Mitochondrial Biogenesis: AMPK activation linked to increased mitochondrial density and oxidative capacity in animal research.
  
• Endurance Studies: rodent models showed improved exercise endurance independent of training.
  
• Insulin Sensitivity: research suggests modulation of glucose homeostasis pathways and improvements in insulin sensitivity in animals.
• Cardiovascular: potential involvement in ischemia protection models via metabolic shift to energy-efficient pathways.